Is promethease worth it reddit 23andme does not provide a full picture here - but this is worth looking into deeper. 1K subscribers in the promethease community. Hi. If you want to look at health stuff, you can always spend $15 for a Promethease report. So, any ideas what is happening!? Here is the stack : Traceback (most recent call last): In order to better sort data Promethease has "magnitude" as an indicator. There has been a lot of research on the microbiome's interaction with those diseases. It's hard to navigate and I don't know how to find all of the information, but it did say that some antidepressants would likely be less effective for me because of One of my hits in Promethease is the following: gs224 "You have two copies of a GCH1 variant associated with lower levels of tetrahydrobiopterin (BH4) and total biopterins. it's worth the price to upgrade. If you have autism/Asperger's and this is literally your only genetic marker related to it, then that would tell us a really interesting thing: someone can be autistic with barely any genetic influence! A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. However if you do an ancestry test with 23 or ancestry dna you also can upload the raw results to companies like promethease which compare it to their entire research database which will give you an overwhelming amount of health info A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. 23andMe is a toy and adding a bunch of research stuff doesn't make it useful. vcf (13 GB) using my updated chrome browser i get this message. g. I had started a process where I was goin While I understand that you can upload the 23andMe info to Promethease, I heard that a Promethease report based on Ancestry raw data contains more than twice as many genotypes as 23andMe. With the ancestry one you still get your raw DNA file. A place for discussing Promethease, a report about your DNA based on the scientific literature cited… I need some help understanding my Promethease results. How often is it worth pulling your results again? I pulled my data about three years ago. See full list on selfhack. I have a BRCA test and mammogram concerning a lump next week. Warning: if you haven’t yet done a Promethease or codegen report and decide to do one you will see a LOT of things that look much scarier than this impute. My Promethease Report lists the magnitude for my two BRCA1 variants as 1. Promethease is a literature retrieval system that builds a personal DNA report based on connecting a file of DNA genotypes to the scientific findings cited in SNPedia. I did the report and I was satisfied with what I paid for. codegen. Then you download the Enlis Genome Browser. On my main page, it shows mostly the "bad repute" items and most of them are a bit concerning. After I was diagnosed with breast cancer and genetically tested it was confirmed that I have "the BRCA1 mutation" implicated for breast cancer. The expert said it isn’t a straightforward Disease like that and full gene testing would need to be done which I didn’t do. Promethease is by far the best third-party data analysis tool, but there are many others out there to choose from. 1 hmm, interesting 3 Probably worth your time 4 Male/Female sex calls, used for QC, anything above this is definitely something you should pay attention to 10 Really significant information! We would like to show you a description here but the site won’t allow us. Or am I fucked Anyways, which one should I trust more. Nebula Genomics. He gave humans fire, but was punished for it, since fire can be used for both good and ill. Expand user menu Open settings menu. A 4 magnitude in and of itself should most definitely looked into further and not disregarded. It can empower users to make informed health decisions. iobio proficiently, use 3rd party analysis tools proficiently, etc, then Nebula data won't be that useful to you and probably wont be So I guess it comes down to whether the extra cost of 23andMe health info on top of Promethease is worth it vs. Generally, many clinics do want to do confirmatory genetic testing since your testing positive on a snp chip like this, even with the false positive rate, increases the chances that you could have a real mutation. It’s also worth mentioning that the very common heterozygous genotype (A;G) sometimes shares the same outcome in studies as the ‘empathetic’ genotype (G;G). We would like to show you a description here but the site won’t allow us. 4K subscribers in the promethease community. It's a bit harder to read and navigate, but you'll save money. Land. I ordered whole genome sequencing and looked at for a week, all was well and good, then I realized there was a surprise $40CAD MONTHLY SUBSCRIPTION FEE to keep access to my own fkn data. Genetic Life Hacks was the only one that flagged a fairly rare gene variant that was causing my chronic cough (Alha-1 Antitrypsin Deficiency). BH4 is used in the production of several neurotransmitters, including serotonin and dopamine. I thought that the $30 was well worth it. This variant is believed to cause autosomal dominant hypercholesterolemia with imperfect penetrance. e. Anything above magnitude 3 might be worth paying attention to. vcf (987 MB) and PG000XXXX-BLD. When I was in a spot where I was a bit suicidal and awfuly ridden with anxiety - I genuinly didnt know if going would be worth the trauma that my friends who were there spoke to me about. I also notice a lot more "likely miscalls" in my Ancestry kit than I do with 23andMe. Members Online Does this snp mean I have a lower risk of developing SCJD A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. It’s cheap, but is it helpful? Learn about its pros and cons in this Promethease review. 9x increased risk for coronary artery disease. Biomedical researchers, healthcare practitioners and customers of DNA testing services (such as 23andMe , Ancestry. Oct 20, 2021 · Takeaway: Is learning how to read Promethease reports worth it? Promethease offers an affordable option if you want to know more about your genetic risks to certain health conditions. There is also risks vs rewards to consider-having your dna in as many databases as possible gives you access to the most other test takers-which can be very valuable for breaking through brick walls-and you need to decide if that benefit is worth it to you (not knowing what may happen with these companies in the future). Exactly, BAM is basically the main file, and the rest of files contain part of its info (SNP. Are you looking for something more than just what the other copy might be? For what it’s worth, snpedia says the criteria for the gs are rs429358 and rs7412 — those two entries have info you might find useful. Plus, hospitals just put you on meds and keep you not dead, thats it. Save the money and just do the ancestry. 7%, so that doesn't make me feel better! I am sorry to hear that. SNPedia says to post questions here. Not a test per se but maybe worth looking into. A generic counselor is a must during these situations, if you primary care physician can provide interpretation, as well. Especially since you've had symptoms, I'd think it would be important to seek advice and insight from a dr. It's worth remembering that Promethease is named for Prometheus. Promethease takes your 23andMe data and shows it nicely formatted by gene etc, drawing directly on the snpedia database of research, I don't think it's making any judgements or interpretations of its own. So I plugged my data into Promethease. Trying to use that for diagnostic purposes is circular at best. Selfdecode is more interpretive, they have staff drafting reports. Reply reply Aug 21, 2020 · The conversation about Promethease on Reddit . I am a huge fan of Promethease for this reason-- it is a cost-effective way to see if there is anything that really warrants discussion with a genetics professional-- I recommend sorting by "Magnitude", and anything rated as 4 or higher might be worth looking at further-- if this is the case for you, then I recommend being very specific when We would like to show you a description here but the site won’t allow us. I won't comment on these variants because they can't be interpreted in a meaningful way. rs121908801(D;I) is not an obvious miscall, and if true, would just mean you are an unaffected carrier of a single cystic fibrosis mutation. Let me know if you need any more help. 4x risk of thrombosis (magnitude 4. 1 hmm, interesting 3 Probably worth your time 4 Male/Female sex calls, used for QC, anything above this is definitely something you should pay attention to 10 Really significant information! He recommended I do a 23andMe test while he researched other conditions. Check out Genomapp. I have a promethease test from 2015, would it be worth rerunning the same data from 23andMe to see what new research appears? Or will it be… 8. I felt it was pretty interesting as it highlighted risks that I know to be in my family, and even identified the fat gene and one that is a possible marker for penicillin allergy. They have all kinds of health reports and a rarely mentioned feature is you can upload all your blood test results and track them over time with recommendations to get into optimal levels. I put my Genos (75x) results to Promethease I think in the last data update in December, probably through "Promethease compatible file". Since you have an interest in genetics maybe you should try ubiome's smartgut test. I took the 23andme genetic test and put my raw data through promethease and it returned 4 different markers for ADHD, which is… Hey guys, I just ran Promethease on both my ancestry, and my 23andme data. Edit: The snpedia APOE link might be more useful. Given that I have regular updates from promethease, what difference does getting another test through the V5 chip or Ancestry DNA make? Does the chip influence the accuracy in a noticeable way that even the promethease report will change? I've seen a slight difference between 23andMe and Ancestry on Promethease (I've uploaded both of mine), with mostly overlap. It seems to me that, at the moment, Promethease might be the best way to get useful medical information. Anything at 3 or lower are mostly curiosities. You pay promethease a little bit of money and they generate a report based on information in SNPedia. Hey everyone. What do you think? Is it worth it? Also, what else can I do with my DNA? I remember reading a few years ago about Promethease for health ‘analysis’. Below is a table containing my ADHD-related findings from my Promethease report. I didn’t have to do any conversations at all. Lots of people find it fashionable to be mixed and that’s not going to apply to most South Asians, while there’s another crowd that wants to confirm a 100% ancestry. Y-12 is a waste of time. Your Promethease report should have shown that CHEK2 mutation, which is known as rs555607708 to most of the world but is named i4000462 by 23andMe. Log In / Sign Up; Advertise on Reddit I only did ancestry then promethease. ) Traits - Fun but not really worth it 3. Plus, there's always Promethease, although the info on 23andMe tends to be more direct and validated. Promethease is great, and codegen. I'd say it was worth between $75 and $125, but not the price of $250, Oh, I had no idea they were charging that much. The trait reports aren't worth it, and I found that mine were off in some cases. Note that this particular mutation is linked to a somewhat more moderate (~2-5 perhaps) increase in risk for breast cancer than are the more pathogenic BRCA1 and BRCA2 mutations, but does also have some other cancer risks as you mentioned. Posted by u/Becca4130 - 4 votes and 13 comments I only had 1 "bad" tagged result filtered with a 3 magnitude or higher on Promethease which was: rs1333049(C;C) 1. 7. Promethease and 23andMe Health Alternative The good news is that Promethease and 23andMe can be complementary services – you can use your raw DNA data from 23andMe to access Promethease’s That’s what promethease said with a note it might be more serious with another genes involvement. Promethease's magnitude value helps a bit with this as very damaging variants for which there is a lot of evidence for pathogenicity should have higher magnitude scores. Promethease's key advantage is identifying genetic variants linked with specific health conditions. Hi! For some reason promethease is giving errors with the VCF that Nebula provides. A place for discussing Promethease, a report about your DNA based on the scientific literature cited… May 13, 2025 · Promethease takes this a step further with a deep dive into health and trait analysis. eu is a decent free alternative to Promethease that gives you much of the same information. Ancestry's DNA sample is slightly bigger than 23andMe's. It's ambitious, trying to be high end. rs4420638 is a proxy snp for the APOE4/4 variant which is extremely well-established as a risk for AD (Alzheimer's Disease) but there are more direct ways of reading for that. rs7158782(G;G) 4x higher risk of adverse side-effect if taking aromatase in 2 looks interesting enough to be worth reading 2. As long as you enter into the agreement knowing that you might find out less-than-stellar information, and do your research around genes, you'll be fine. I know it's pretty common to get a lot of bad results, but what freaked me out most was a 3. In Dec 9, 2021 · Also in 2019, Reddit users reported that MyHeritage gained access to their raw genetic data from Promethease even after they deleted their information. Apparently it's pretty rare with a frequency of just 2. rs909525 C rs6323 T rs3027399 G On Promethease. They’ll email back offering 50% off that. Took four days, but oh well. 18 votes, 11 comments. Read more in our Promethease review! Promethease provides detailed health reports for a price lower than most competitors. Hi, I've been doing similar genetic reviewing. It is not a super useful test yet, but arguably more so than testing your own genes for this. 5-4. These are just the usual results everyone has aren't they? my worst are: rs1333049(C;C) - Magnitude - 4 - 20. Sequencing. One option is GEDmatch to widen my matches (didn’t get many useful on Ancestry alone), but I’m concerned about it’s history with allowing third parties access to its data. I created my Promethease account and exported my 23andme data. Step 2: On the right-hand panel This is only tangentially related, but I did 23andme and then submitted my information to a third party site (Promethease), which has some information about medication hidden in it. genome. One of my favorite quotes is Adam Savage's "If it's worth doing, it's worth overdoing". vcf (152 MB) but when I try to upload PG000XXXX-BLD. A place for discussing Promethease, a report about your DNA based on the scientific literature cited… Then offer to sell you the whole annotating thing, but wait a few days. I was going to edit my Tellmegen file but it’s inconsistent on what things are like, scored in a way that is seen as “opposite” in promethease (where you’ll get false positives) and what things are like, straight with SNPedia and stuff. One thing to keep in mind is that if your raw data came from 23 and Me or Ancestry. Dr. very little of the genome was actually surveyed), it can also mean that the person isn't carrying a known, "nasty" genotype such as one often leading to an unwanted medical condition; in other For each of these SNPs, the Promethease curated report will tell you if you have the common or the risk variant. Yes, I think Genetic Life Hacks is the most useful one I have used, including Promethease, Genetic Genie, and Nutrahacker. 23andMe has a 99. rs5848 is not very well researched yet, I wouldn't put much weight on it. Some users found that their genetic information had been acquired by MyHeritage despite their attempts to delete it from the Promethease databases. Is that true? So I guess it comes down to whether the extra cost of 23andMe health info on top of Promethease is worth it vs. Particularly my chances of the disease that it may contribute to. Anything under 4 isn’t worth spending too much time looking at. The conversation about Promethease on Twitter I have been listening back to some older episodes as well as listening to the book on audio and the newer episodes and genetics obviously comes up often. rs909525(G;G) --> Perhaps MAOA 3 repeats: Warrior Gene? rs6323(T;T) --> reduced MAOA activity rs3027399 --> not found in Promethease report A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. The interface could be difficult for first time users. If I search “apoe” in Promethease it gives me gs246 for a genotype. It would certainly be worth mentioning to your Dr. You also need to consider the evidence that is being used to claim an increased risk of MS. VCF are just genetic differences in your genome when compared to the reference genome, the file is empty for info that fits the reference genome, and shows as incomplete when uploaded to Promethease. Purchased the ancestry kit for $83 and was quite pleased with the report. I was wondering if it would be worth my money to upload it to promethease, since they test for a lot of… It's concerning to note that earlier 23andMe chips identified this as CC, while newer ones might show it as II. if you have time look her up on Joe Rogans Podcast. While I understand that you can upload the 23andMe info to Promethease, I heard that a Promethease report based on Ancestry raw data contains more than twice as many genotypes as 23andMe. considering its deadly. It may be worth downloading a fresh raw data file to check for any discrepancies or changes. me result so if you’re easily made anxious or don’t want to do the research to understand what it means/touch up on statistics then I strongly advise you don’t do one as the things it For what it's worth, the report I'd been trying to get came through this AM. Is promethease still worth buying or is the information on free websites like codegen enough? Jul 19, 2024 · Promethease is by far the best third-party data analysis tool, but there are many others out there to choose from. Also just know that Ancestry seems to give a lot of weird misscalls with Promethease, so if some rare genetic disorder/disease shows up just know it may just be I got the health analysis for free because I participated in a study, thankfully, because I definitely would not have paid for it. So, I just got back my Ancestry DNA results. com has their eve premium service, which is worth looking into. My grandmother recently passed at age 80 from complications of this exact thing, but she was a lifelong smoker which may have exacerbated her risk factors. I have a family history of autoimmune and diabetes so I felt like it was it was worth the investment. The rules of Promethease are to double check the research behind the genes. 4% Frequency 1. here’s what it gave me/ what i found interesting: just wondering if it's worth it to also run decodify me?? thanks. For what its worth I am 100% European so that could explain why I have a lot of genes related to balding? I do also have GS122 but I heard that isn't really a good way to predict balding. It is more of an educational tool than a health driven tool. The reports are as accurate as the source material. Folks - please don’t let these people anywhere near you or your genes. I’ve been suffering from RA for 6 years. A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. Some of the details of the items say it occurs in people of "European descent" etc. Just depends if Promethease is up to date on the SNP in question. Members Online Does this snp mean I have a lower risk of developing SCJD An important (and humble) comment here - genetic profile does not correlate with gene expression. I've tried responding to the Processing Delay emails, and going to the Help/Contact section of Promethease. It’s not full genome testing. If you don't mind me asking, what was your response to seeing the genes linked to schizophrenia show up in Promethease? Have you made any lifestyle changes as a result, or has it had any impact about how you view yourself? Yinwang888's post on schizophrenia and promethease worth a read if you haven't see it already. Both Genie and Prom correctly picked up my carrier status for a common recessive condition, but both missed the second (rarer) disease for which I’m also a carrier 🤷‍♂️ I was wondering if anyone has any input on if it’s worth going for the most expensive kit? The more expensive one is giving you health information. I have a basic question about the "Magnitude" designation on Promethease as it relates to the BRCA1 gene. If you have Promethease (worth getting if not) it says "rs4420638 It's not worth worrying about, trust me. Moreover, Promethease expands trait analysis beyond basic characteristics. We did it years ago, for $100. About half of dominant health conditions are wrong. If you decide against getting the health portion and instead only getting ancestry, you still can get quite a lot information by uploading your data to Promethease, FoundMyFitness and other sites. I used my 23andMe file on SelfDecode - worth it imo. As it is, they don’t offer a DNA test, so you’ll need to get your DNA tested by another company before using this platform. Also, when using promethease for health markers you should change the magnitude to 4. The other . Imho it's rather expensive. That community means very well and are well-versed in SNPs, but are not guaranteed to know "for sure" how important a mutation is. At least I got my report and didn't lose the money I'd paid. However, if you used promethease, you should just be able to search in their results (search for "celiac" and read through the results; there are a lot that simply contribute to the risk or not, but the DQ2/8 stuff should be in there as well). I'm contemplating upgrading to the $125 health data package. ) use Promethease to retrieve Jul 19, 2024 · If you're interested in getting more health-related info out of your data, Promethease is a tool that may be of interest. Obviously, if you do Big Y, FTDNA will include more SNPs and therefore be further downstream than 23andMe, but Big Y is expensive and personally, I don't think it's worth it just for a haplogroup. I think so. 23&Me doesn't have these issues, everything connects to you and they make the conclusions for you. Related Topics Genealogy Family Family and Relationships 2 looks interesting enough to be worth reading 2. If you get a y-DNA test, I recommend the Y-37 or higher test. I'm willing to bet there's some mutations that are worthy of investigation that have yet to even be marked. Nebula Genomics stands out compared to other genomic health reporting services. How accurate would you say Promethease is as a 1. My main purpose of getting DNA tests is not to track ancestry, but so that I can run the raw data through Promethease and similar sites to generate… Note that this file used to work, and I had a report from Promethease last year. In addition, Promethease is a "look up table" that looks into public databases to see if there is any information about the meaning of the variant. Posted by u/Similar_Touch3943 - 1 vote and 3 comments thanks for confirming! i paid for a month and it gave me some info that reminded me of promethease as far as drug metabolization. You'll see that in your Promethease report rs587779548(G;G) is outlined in green, which means it's a common/normal/good genotype, and, the summary tells you it's the common form, and, the Repute says "good", and, the magnitude is zero. 1 and 2. You might want to weigh whether you want to know that at all. com Sep 16, 2021 · Promethease provides a report based on your raw DNA data. 23andme, or Promethease. Thank you so much. I'm wondering if anyone else has some good insight on this. Promethease is a good tool if you know what you're doing with it. i agree that it’s not worth $10 a month, but may be worth it to some to pay for a month. Promethease is very comprehensive but it's not the most user friendly. 6K subscribers in the promethease community. Is there a way to generate a VCF file or a gVCF one to use with promethease using WGSextract? Does is the combined kit accepted by promethease? What's the difference between the reference genome (Hg19 - Hg38)? Gilbert’s syndrome is pretty harmless. and if my break down on maybe having a 0. Members Online Is promethease still worth buying or is the information on free websites like codegen enough? If you're not a person who can comb the literature and compare it to your data, having the skill to convert from Ch37 to Ch38 to T2T, use tools to convert CRAM files to other formats like 23 and Me etc, use gene. We prioritize privacy above all else. 02 percent chance of developing the disease with this allele, is in fact generally accurate. They don't sell Y-12 anymore, it starts at 37. Rhonda is incredibly knowledgeable about nutrition and genetics. rs62508727(D;I) is likely to be a miscall as your Promethease report presumably says (when seen in 23andMe data). Dante Labs sequencing is way more accurate. The manual explains how to do it and is worth a read but i think you'll just need the cram, crai, the reference genome of the nebula file (hg38) and the one your aligning to which you select when setting it up. just uploading raw data from I can't answer your question directly, but in another thread I remember a discussion about magnitude in promeathease being significant and worth investigating if above a 4. Is it worth it to do it again, or would the results pretty much be the same? So it doesn’t test for everything. Jul 5, 2022 · User reviews of Promethease on Reddit compare Promethease to Xcode Life. ) Ancestry Composition - Depends. . They both take you to a blank wiki. Members Online The genealogy subreddit auto deleted my post and I can't copy/paste the words. Each of the SNPs also comes with a Promethease magnitude definition, on a scale from 1 to 10, where >3 is “probably worth your time”, and this line is crossed for some of the Schizophrenia risk SNPs (e. ) Health - Worth it 2. Thanks JohnBoddy, for sharing. Feb 4, 2019 · Promethease — a tool for anyone to understand genetic health risks; 3 filter suggestions for your report; The missing 4 are likely not worth looking at. Every single blood test I’ve ever had I’ve had mildly elevated bilirubin levels. Here is a link to my Promethease report. I worried for maybe a day or two, looked up some stuff online, and that's that. Promethease is slightly more reliable, but there’s a fee yet there is virtually no customer service to show for it. To put it into context, ~60% of people have the variant allele which confers its own (to a lesser degree) advantages. 1 being the highest I could go). SNPs. Promethease shows the data provided by you that overlaps with SNPedia, including showing you the normal forms when they are present. They have been known to get a number of things wrong. Really depends on motivations. It shows a lot more information than 23andMe with a lot more junk. 4. Totally worth it. eu is a free health service that gave similar information as Promethease. 9x increased risk for coronary artery disease For what it's worth, the magnitude is defined by a community. Here is my methylation panel from Genetic Genie. Considering current symptoms being similar and a frequency under 1%, in my non medical unprofessional suggestion, I would say you either have it, will have it, or have very similar symptoms shared with Crohn's and that steps should be taken with a medical professional and changes to diet and A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. I have found some free services and some paid reports that have been really helpful in addition to promethease. Indels. For me accurately predicted high incidence for Rheumatoid Arthritis and Her+ Breast Cancer. I had uploaded it elsewhere in at least one additional database. There's a possibility that the data science team at 23andMe has recently adjusted the raw data. That has become a life motto for me Anyway, I got the raw data from 23andMe and put it in Promethease and DNA. i have it merged with the 23andme data, which were around 19960 in the January 2017, and the merge has 22477 variants listed in Promethease (with 11 conflicts, 2 of which were actually just different naming of My MAO-A Results On 23 and me. There is also Promethease which accepts DNA samples from other sites and analyzes them for more detailed health results. Although this can mean the raw data isn't very comprehensive (i. Depending on the specific allele Promethease tests for, your risk of MPNs may be higher than normal, but MPNs in general are rare, so your relative risk would likely still be low. I don't know why I started freaking out over this again. Jul 5, 2022 · Promethease predicts disease risks from uploaded DNA data, but the results can be difficult to understand. Promethease is an established and reliable company, they are actually now owned by MyHeritage. The UI is slightly better. Reddit users have expressed serious concerns about the validity of Promethease’s commitments to privacy. 5 accuracy rate. I think is very worth it. Posted by u/katlyn8638 - 11 votes and 15 comments Posted by u/katlyn8638 - 11 votes and 15 comments My main purpose of getting DNA tests is not to track ancestry, but so that I can run the raw data through Promethease and similar sites to generate… I think it's important to note that there will be conflicts detected, but these conflicts should be listed by promethease. My primary motivation is proactive health management, but I'm concerned about potential ramifications for future health insurance eligibility. At some point I asked about it and my PCP said that tons of people have Gilbert’s disease and it doesn’t really need to actually be treated. It’s amazing and you can look into so much more, including the SNPs that Promethease and the others ignore since they’re not known/confirmed mutations. There are some contradictory things in Promethease as well as things that won't apply to you. Worth the few quid it cost to have a look anyway! I have successfully uploaded the following files to promethease PG000XXXX-BLD. 1, with 4. It's not always easy to tell what the bottom line is. The reason for doing so was due to me researching Parkinson's disease, as I feel I may present symptoms of early onset Parkinson's, and I found out this may be a way to check my DNA for links. just uploading raw data from What did you run through promethease? Promethease is only as good as the data put into it. ) By the way, many Promethease reports have no genotypes of magnitude higher than 4. We also offer whole genome sequencing, the most advanced genetic test. 5% puts in some serious errors sometimes. The problem is that we know these databases are wrong ~25% of the time. But you can't test at Promethease, you can only upload your raw DNA data there, and they will accept uploads from pretty much any testing company. Think of this as motivation to better yourself since you're starting with a disadvantage you cannot control. If you find anything worth digging into, make sure that SNP isn't on the conflict list and always reference it against nebula's information to ensure accuracy using this method. Promethease is more work. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Just look up your raw data on 23andme if you don't want to pay the $5 for promethease (worth Promethease wouldn't be testing for JAK2 V617F as it's somatic in origin. As someone that doesn't know much about this, what would you recommend doing to get your money's worth and the best useful practical understanding with the data? Will I be able to find out easily if SAMe or piracetam is going on work well on me, for example? You have one snp that's been identified as having a positive link to autism. but I am of Asian ethnicity with no European traces. just uploading raw data from Ancestry. Basically if you have more time than money, do Promethease. Most genetic data comes from retrospective cohort studies, so we don't have a good way of looking at epigenetic and environmental influences and whether or not these genes are active / influential in any specific individual. rs4129148, level 3). com , FamilyTreeDNA , Genos , etc. luamd myqnrx cwrl xcqtuvh fgequ qjyj srgd hxfks eiyz tdefgiaw